Author: briefly

Industrial policy for the Intelligence Age

Explore our ambitious, people-first industrial policy ideas for the AI era—focused on expanding opportunity, sharing prosperity, and building resilient institutions as advanced intelligence evolves.

OpenAI acquires TBPN

OpenAI acquires TBPN to accelerate global conversations around AI and support independent media, expanding dialogue with builders, businesses, and the broader tech community.

APOE4 Increases Neurons’ Excitability Before Symptoms Appear

The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer’s disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for the common, late-onset form of […]

A Target for Ameliorating Post-Operative Delirium

Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from delirium after surgery [1], which rises to around half if the surgery is particularly invasive or high-risk [2]. This increases the length of hospital stays […]

Insilico and Eli Lilly Announce a Major Collaboration

Building on two previous deals between the companies, this new agreement is potentially worth up to $2.75 billion and involves Lilly licensing assets from Insilico’s pipeline. More than software Earlier this week, the AI-driven drug discovery company Insilico Medicine announced a large-scale collaboration with the pharmaceutical giant Eli Lilly. The deal is worth up to […]

How an Enzyme’s Depletion Makes Fat Worse

In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it […]

Becoming Well-Fed and Sedentary Accelerates Penguin Aging

A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and changes in metabolic pathways [1]. A unique model system A sedentary lifestyle and obesity are linked to accelerated aging in humans and, at the molecular level, […]